Mal/Inara is my main Firefly OTP so the whole Kaylee/Inara never occured to me at all until your comment brought it up. I had originally come out of it with all sorts of bittersweet Mal/Inara feelings.

Yes, canon did set it up but it just never resolved itself emotionally. Which was one of the points that disappointed me about Serenity. Simply because I didn't get the resolution I wanted for both Mal and Inara in regards to their feelings towards each other. I suppose because of that in my head their relationship never quite felt canon to me.

I only thought of the possibility of Kaylee/Inara when you brought it up in the comments. But honestly now that I think about it, is completely plausible because they are compatible in the whole no-strings-attached, this is what we want in the moment sort of thing.